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  • Disseminate information on the benefits of screening for early detection to the public and health care providers. Current evidence-based screening tests include:
    • Mammography for
    • Endoscopy and/or fecal occult blood testing for
    • Pap tests for
    • Skin self-examination and physical examination for
    • Other screening tests as developed
  • Emphasize screening education in communities with identified .

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  • Disseminate information on increased risk of:
    • Diets low in fruits and vegetables, as diet is related to 30% of all cancers
    • Breast, esophageal, and head and neck cancer with more-than-moderate alcohol use
    • Colon and breast cancer with high dietary fat
    • Lung cancer with radon exposure
    • Lung, breast, cervical, kidney, head and neck, pancreas, colorectal and bladder cancer with tobacco use, from both primary and second-hand smoke exposure as tobacco exposure is related to 30% of all cancers
    • Skin cancer with ultraviolet exposure
    • Support programs increasing the general population’s knowledge regarding familial risk, genetic testing and counseling, treatment options, and best practices.
    • Provide education to health care providers to increase use of appropriate family history risk assessment tools for individuals in the following high risk groups:

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    Breast cancer

    Breast cancer, especially under age 50

    Male breast cancer

    Ovarian cancer at any age

    Jewish ancestry

    Non-medullary thyroid cancer

    Hereditary Breast/Ovarian Cancer (HBOC); Cowden Syndrome;  Li-Fraumeni Syndrome; or Neurofibromatosis type 1

    Inherited mutations in BRCA1/2, PTEN, p53, or NF1 genes

    Colorectal cancer

    Colorectal and/or endometrial cancers, especially under age 60

    Ovarian cancer at any age

    Multiple colon polyps (10 or more on a single screening)

    Hereditary Non-Polyposis Colon Cancer (HNPCC, aka Lynch syndrome); Familial Adenomatous Polyposis (FAP); or MYH-Associated Polyposis (MAP)

    Inherited mutations in MLH1, MSH2, MSH6, PMS2, APC, or MYH genes

    Ovarian cancer

    Breast cancer, especially under age 50

    Ovarian cancer at any age

    Male breast cancer

    Jewish ancestry

    Hereditary Breast/Ovarian Cancer (HBOC); Hereditary Non-Polyposis Colon Cancer (HNPCC, aka Lynch syndrome)

    Inherited mutations in BRCA1/2, MLH1, MSH2, MSH6, or PMS 2 genes

    Melanoma

    Melanoma

    Thyroid cancer

    Thyroid or breast cancer

    Multiple Endocrine Neoplasia type II; Cowden syndrome

    Inherited mutations in RET or PTEN genes

    Prostate cancer

    Prostate cancer

    Endometrial cancer

    Colorectal and/or endometrial cancers, especially under age 60

    Ovarian cancer at any age

    Hereditary Non-Polyposis Colon Cancer (HNPCC, aka Lynch syndrome)

    Inherited mutations in MLH1, MSH2, MSH6, or PMS2 genes

     

     

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Strategies:

  • Provide education to health care providers to increase use of appropriate assessment tools in the following high- risk groups:
    • Breast cancer in women with first- degree relatives with breast cancer, especially under age 50 and/or ovarian cancer at any age
    • Breast and ovarian cancer in women with BRCA1 and BRCA2 gene mutations
    • Colorectal cancer in persons with first- degree relatives with colorectal cancer, especially at age less than 60
    • Melanoma in persons with first-degree relatives with melanoma
    • Prostate cancer in men with first- degree relatives with prostate cancer
    • Thyroid cancer in persons with first- degree relatives with thyroid cancer or multiple endocrine neoplasia type II
  • Support programs increasing the general population’s knowledge regarding familial risk, genetic testing and counseling, treatment options, and best practices.

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  • Disseminate information on clinical trials via the Colorado Cancer Coalition website at about ongoing clinical trials in chemoprevention at the following sites; UCCC, CCRP, and RMCC.
  • Support establishment of professional training mechanisms, which will increase knowledge about clinical trials.

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